探真生物拥有先进的多肽合成能力,并提供超过300种的修饰类型,能合成mg级到公斤级的规格,以满足您在不同客户的需求。


N端或侧链氨基的修饰 乙酰化 (Acetylation) 甲酰化 (Formylation) Hynic
生物素标记 (Biotin) 脂肪酸修饰 (Palm, Myr,Lauryl) DOTA、NOTA (Chelating Peptides)
三氟乙酰化 (TFA) 苯甲酰化 (Bzo) 肽核酸(PNA)
2-氨基苯甲酰化 (Abz) Maleimide 叶酸
氯乙酰化、溴乙酰化 Suc修饰 任何其他化合物

C端或侧链羧基的修饰 酰胺化 (Amidation) pNA FMK
酯化 (Esterification) 琥珀酰化 (Succinylated)
AMC 醛基化
AFC Maleimide 醇基化


特殊氨基酸
{d-ALA} Alanine {NVA} Norvaline {pTYR} Phosphorylation (TYR) {Lys(biotin)} Biotin Lysine {D-2-Nal} {L-4-Pal} {Mini-PEG1} {PEG2} NH2-(PEG)2-CH2COOH
{d-ARG} Arginine {d-NVA} Norvaline {gamma-GLU} Gamma-GLU {Cys(Acm)} Cysteine (Acm) {D-3-Pal} {Lys(5-FAM)} {Met(O)} Methionine sulfoxide {PEG6} NH2-(PEG)6-CH2CH2COOH
{d-ASN} Asparagine {ORN} Ornithine {d-gamma-GLU} D-Gamma-GLU {Cys(tBu)} Cysteine (tBu) {D-4-F-Phe} {Lys(Dansyl)} {Met(O)2} Methionine sulfone {PEG11} NH2-(PEG)11-CH2COOH
{d-ASP} Aspartic Acid {d-ORN} Ornithine {CIT} Citrulline {d-1-NAL} (D) 1-Nal {D-4-I-Phe} {Lys(FITC)} {Cpg} Cyclopentylglycine {PEG12} NH2-(PEG)12-CH2CH2COOH
{d-CYS} Cysteine {PEN} Penicillamine {nme-ALA} N-methylated ALA {L-1-NAL} (L) 1-NAL {D-4-NO2-Phe} {Lys(Me)} {Pra} Propargylglycine Dab(Dnp)
{d-GLU} Glutamic Acid {d-PEN} Penicillamine {nme-ILE} N-methylated Isoleucine {d-2-PAL} (D) 2-PAL {D-4-Pal} {Lys(Me2)} {Tic} 1,2,3,4-Tetrahydroisoquin oline-3-carboxylic acid Dap(Dnp)
{d-GLN} Glutamine {d-PHE} Phenylalanine {nme-LEU} N-methylated Leucine {L-2-PAL} (L) 2-PAL {D-Beta-Asp} {Lys(Me3)} {Sec} Selenocysteine Dpa
{HCY} Homocysteine {d-PRO} Proline {nme-PHE} N-methylated Phenylalanine {d-4-CL-PHE} (D) 4-CL-PHE {D-Cha} {Lys(TMR)} {Se-Met} Selenomethionine Lys(Dde)
{d-HIS} Histidine {d-SER} Serine {nme-VAL} N-methylated Valine {L-4-CL-PHE} (L) 4-CL-PHE {D-Chg} {NMe-Asp} {Lys(N3)} Azido-Lysine Lys(ivdde)
{HSE} Homoserine {d-THR} Threonine {nme-SER} N-methylated Serine {ABU} Abu {D-Cit} {NMe-Glu} {Beta-HomoLeu} Beta-HomoLeucine Oic
{d-HSE} Homoserine {d-TRP} Tryptophan {nme-THR} N-methylated Threonine {AIB} Aib {Dab} {NMe-Nle} {Cys(Cam)} Carboxyamidomethy lated Cysteine Pip
{d-ILE} Isoleucine {d-TYR} Tyrosine {nme-TYR} N-methylated Tyrosine {MPA} Mpa {Dap} {NMe-Nva} {Arg(Me)} Methylation at the side chain of Arginine Tle
{d-LEU} Leucine {d-VAL} Valine {alpha-ABA} Alpha Amino-Butyric Acid {HYP} Hydroxy Proline {L-2-Nal} {Phg} {ADMA} Arg(Me)2 asymmetrical
{d-LYS} Lysine {pGLU} Pyroglutamate {Beta-Asp} Beta-ASP {Lys-Ac} Acetylation at the side chain {L-3-Pal} {Ser(octanoic-acid)} {SDMA} Arg(Me)2 symmetrical
{d-MET} Methionine {Lys(Dnp)} Dinitrobenzylation (LYS) {Ac-LYS} Acetylation at alpha amine group {Cha} {L-4-F-Phe} {d-HCY} Homocysteine {Beta-Ala} Beta-Alanine
{NLE} Norleucine {pTHR} Phosphorylation (THR) {2-Me-ALA} 2-Methyl Alanine {Chg} {L-4-I-Phe} {d-pGLU} Pyroglutamate {GABA} 4-Aminobutyric acid
{d-NLE} Norleucine {pSER} Phosphorylation (SER) {nme-GLY} N-methylated Glycine {D-2-Me-Trp} {L-4-NO2-Phe} {nme-MET} N-methylated Methionine {Ahx} 6-amino-hexanoic acid


甲基化及其它烷基化修饰 N-甲基化修饰 NMe-His、NMe-Met、NMe-Gly、NMe-Ala、NMe-Asn、NMe-Asp、NMe-Arg、NMe-Cys、NMe-Glu、NMe-Gln、NMe-Leu、NMe-Ile、NMe-Lys、NMe-Ser、NMe-Thr、NMe-Trp、NMe-Val、NMe-Nle、NMe-Phe
其他位点甲基化修饰 Lys(Me)、Lys(Me)2、Lys(Me)3、Arg(Me)、Arg(Me)2S、Arg(Me)2AS、Cys(Me)、Asp(OMe)、Glu(OMe)、Tyr(Me)、Trp(Me)
其它的烷基化修饰服务 N-乙基、N-苯丙基、N-烯丙基、Tyr(Et)、Trp(For)、Ser侧链烷基化


同位素标记 多种氨基酸 (D型以及L型)的13C,15N,D以及18O的同位素标记


单荧光修饰 FAM FITC TAMRA
Bodipy Edans Cy 系列
AMC Atto 系列 Alexa Fluor 系列
Tide Fluor 系列 7OHCCA Dabcyl
DansylChlorde Texas Red DACIA
多荧光修饰 多肽中修饰2种以上荧光,如: Cy5+QSY21,6FAM+QSY9,FITC+5FAM,DNP+DACIA,Tide Fluor 555+Tide Fluor 647, 等


侧链修饰 Phe衍生物 Phe(4-Cl)、Phe(4-NO2)、Phe(3-Cl)、Phe(4-CF3)
Ser侧链烷基化 Ser(Butanoyl)、Ser(Octanoyl)、Ser(Palm)、Ser(Laury)、Ser(Myr)
Tyr衍生物 Tyr(3-Cl)、Tyr(3-NO2)、Tyr(SO3H2)


PEG (聚乙二醇)修饰 PEG2 PEG4 PEG8
PEG12 PEG24 PEG36
PEG2000 PEG4000 PEG5000
任何PEG 结构


环肽 多重二硫键及二硒键(Sec&Sec) 多重二硫键及二硒键(Sec&Sec) 首尾成环
单硫醚环化 侧链成环(内酯、内酰胺、醚键等)
点击化学(Click Chemistry)叠氮与炔基的1,3-偶极环加成反应形成三氮唑结构;或者叠氮与DBCO反应